The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1

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The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.

Alterations in the activity of the centrosomal kinase, Aurora-A/STK15, have been implicated in centrosome amplification, genome instability and cellular transformation. How STK15 participates in all of these processes remains largely mysterious. The activity of STK15 is regulated by phosphorylation and ubiquitin-mediated degradation, and physically interacts with protein phosphatase 1 (PP1) and...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2002

ISSN: 1362-4962

DOI: 10.1093/nar/gkf678